Distinct Pores for Peroxisomal Import of PTS1 and PTS2 Proteins
نویسندگان
چکیده
منابع مشابه
PTS1 Peroxisomal Import Pathway Plays Shared and Distinct Roles to PTS2 Pathway in Development and Pathogenicity of Magnaporthe oryzae
Peroxisomes participate in various important metabolisms and are required in pathogenicity of fungal plant pathogens. Peroxisomal matrix proteins are imported from cytoplasm into peroxisomes through peroxisomal targeting signal 1 (PTS1) or peroxisomal targeting signal 2 (PTS2) import pathway. PEX5 and PEX7 genes participate in the two pathways respectively. The involvement of PEX7 mediated PTS2...
متن کاملpex5 Mutants that differentially disrupt PTS1 and PTS2 peroxisomal matrix protein import in Arabidopsis.
PEX5 and PEX7 are receptors required for the import of peroxisome-bound proteins containing one of two peroxisomal targeting signals (PTS1 or PTS2). To better understand the role of PEX5 in plant peroxisomal import, we characterized the Arabidopsis (Arabidopsis thaliana) pex5-10 mutant, which has a T-DNA insertion in exon 5 of the PEX5 gene. Sequencing results revealed that exon 5, along with t...
متن کاملPex9p is a novel yeast peroxisomal import receptor for PTS1-proteins
Peroxisomal proteins carrying a type 1 peroxisomal targeting signal (PTS1) are recognized by the well-conserved cycling import receptor Pex5p. Yeast YMR018w gene codes for a Pex5p paralog and novel peroxin that is involved in peroxisomal import of a subset of matrix proteins. The novel peroxin was designated Pex9p and it interacts with the docking protein Pex14p and a subclass of PTS1-containin...
متن کاملPex9p is a new yeast peroxisomal import receptor for PTS1-containing proteins.
Peroxisomal proteins carrying a type 1 peroxisomal targeting signal (PTS1) are recognized by the well-conserved cycling import receptor Pex5p. The yeast YMR018W gene encodes a Pex5p paralog and newly identified peroxin that is involved in peroxisomal import of a subset of matrix proteins. The new peroxin was designated Pex9p, and it interacts with the docking protein Pex14p and a subclass of PT...
متن کاملAn isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes.
Mutations in the peroxisome targeting signal (PTS) 1 receptor gene, PEX5 , are responsible for complementation group (CG) 2 of the peroxisome biogenesis disorders (PBD). Of the two reported patients in this CG, cells from PBD018 (homozygous for the missense mutation N489K) are defective in the import of PTS1 proteins into peroxisomes, as expected. However, cells from PBD005 (homozygous for the ...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2015
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2015.11.016